One of OBI’s key goals is to enable researchers to collaborate across disciplines, across institutions and across diseases. Efficient comparison of data (analysis) can only be done when data are in the same format. To properly analyze the vast array of clinical, neuroimaging, and molecular data that will be stored in Brian-CODE, it has to be standardized. Common Data Elements (CDEs) help define and format the different types of variables that researchers analyze . They allow for consistency in data collection across studies, improved quality of the data collected, and they increase opportunities for sharing and cross-study analysis. CDEs also optimize researchers’ ability to analyze large pools of data as well as facilitate its linking with external databases.