Controlled Data Releases

CP-NET Clinical Database Platform: Genomic Architecture of CP (Whole Genome Sequencing)

Cerebral Palsy Neuroscience Discovery Network (CP-NET)
The CP-NET Clinical Database recruits children born in 2009 or later with a confirmed diagnosis of cerebral palsy (CP) and contains data on clinically relevant risk factors, neuroimaging information, and neurodevelopmental functioning including psychosocial and participation outcomes.

This released dataset has whole genome sequencing data (WGS) on 221 children and youth with CP and their biological parents (656 samples). WGS was performed on DNA extracted from saliva on the Illumina HiSeq X platform, and the resulting CRAM files are provided.


Version: 1.0 Date Released: On publication Participants: 221
Files: 656 Size: 46 TB
DOI: 10.60955/fszr-5q79 ARK ID:

Conditions: Cerebral palsy

Modalities: Genomics

Formats: CRAM

For further information

Comprehensive Whole-Genome Sequence Annotation to Elucidate the Genomic Architecture of Cerebral Palsy

Fehlings DL, Zarrei M, Engchuan W, Sondheimer N, Thiruvahindrapuram B, MacDonald JR, Higginbotham EJ, Thapa R, Behlim T, Aimola S, Switzer L, Ng P, Wei J, Danthi PS, Pellecchia G, Lamoureux S, Ho K, Pereira SL, de Rijke J, Sung WWL, Mowjoodi A, Howe J, Nalpathamkalam T, Manshaei R, Ghaffari S, Whitney J, Patel RV, Hamdan O, Shaath R, Trost B, Knights S, Samdup D, McCormick A, Hunt C, Kirton A, Kawamura A, Mesterman R, Gorter JW, Dlamini N, Merico D, Hilali M, Hirschfeld K, Grover K, Bautista NX, Han K, Marshall C, Yuen RKC, Subbarao P, Azad MB, Turvey SE, Mandhane P, Moraes T, Simons E, Maxwell G, Shevell M, Costain G, Michaud JL, Hamdan FF, Gauthier J, Uguen K, Stavropoulos DJ, Wintle RF, Oskoui M, Scherer SW (2024). Nature Genetics.


Additional Resources

About CP-NET Hemi-NET CP-NET Videos


RECOVER: REaching patients with a COncussion Visiting the Emergency Room to enhance care

The RECOVER team of CONNECT - Dr. Andrew Baker, Dr. Cindy Hunt, Dr. Anil Dosaj, Alicja Michalak, Dr. Alun Ackery, Dr. Nathan Churchill, Dr. Michael Cusimano, Dr. Tom Schweizer, Dr. Karl Zabjek
The Concussion Ontario Network: Neuroinformatics to Enhance Clinical care and Translation (CONNECT) is a collaborative network of 10 clinical sites across Ontario that aim to ensure new knowledge of concussion is translated into better diagnosis and care for the benefit of all Ontarians...

Version: 1.0 Date Released: 2023-12-01 Participants: 16
Files: 672 Size: 5.21 GB
DOI: 10.60955/qkh0-cx58 ARK ID: 70798/d7hk4spx56tjf88fhf

Conditions: Persistent post-concussive symptoms

Scans: fMRI (resting state), DTI, T1W, ASL, SWI, FLAIR

Timepoints: Baseline, Follow-up (Week 2, Week 4, Week 12)

Modalities: concussion, PPCS, follow-ups, mood, pain, balance, reaction, sleep, symptoms, abilities, quality of life, treatment, neuroimaging, MRI, locomotion, saccadometry

Formats: BVAL, BVEC, CSV, DOCX, JSON, NIfTI, PDF, XLSX


Ontario Neurodegenerative Disease Research Initiative (ONDRI): Foundational Study Longitudinal Data - Release 2.0

Dr. Mario Masellis, Dr. Douglas Munoz, Dr. Michael Strong, Dr. Richard Swartz, ONDRI study team
ONDRI's Foundational study includes data from 520 people living with Alzheimer’s Disease, Mild Cognitive Impairment, Parkinson’s Disease, Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, or Cerebrovascular Disease, along with their care partners...

Version: 2.0 Date Released: 2023-10-01 Participants: 520
Files: 889 Size: 365 GB
DOI: 10.60955/ygbs-na17 ARK ID: 70798/d7r439px587bx4v6vq

Conditions: Alzheimer's disease, Cognitive impairment, Parkinson's disease, Amyotrophic lateral sclerosis, Frontotemporal dementia, Unspecified cerebrovascular disease

Timepoints: Screening, Baseline, 6 Month, Year 1, 18 Month, Year 2, 30 Month, Year 3

Modalities: Cohort study, clinical, Cognitive, Gait and balance, Eye tracking, Retinal imaging, Genetic markers, Neuroimaging, Neuropsychological assessment, Cross-disease, Cross-platform, Caregiver, Deep pheotyping

Formats: CSV, TXT, NIfTI

For further information

Characteristics of the Ontario Neurodegenerative Disease Research Initiative cohort.

Sunderland KM, Beaton D, Arnott SR, Kleinstiver P, Kwan D, ,Lawrence-Dewar JM, Ramirez J, Tan B, Bartha R & Black SE (2022). Alzheimer's & Dementia.

Integrated Biological Markers for the Prediction of Treatment Response in Depression (Updated!)

Dr. Sidney Kennedy, Dr. Pierre Blier, Dr. Faranak Farzan, Dr. Benicio Frey, Dr. Jane Foster, Dr. Raymond Lam, Dr. Glenda MacQueen, Dr. Roumen Milev, Dr. Daniel Mueller, Dr. Sagar Parikh, Dr. Susan Rotzinger, Dr. Stephen Strother, Dr. Claudio Soares, Dr. Valerie Taylor, Dr. Gustavo Turecki, Dr. Rudolf Uher, and the CAN-BIND Study Team
The Canadian Biomarker Integration Network in Depression (CAN-BIND) is a national program of research and learning. From 2013 to 2017, data were collected from 211 participants with major depressive disorder and 112 healthy individuals with an average age of 35 years...

Version: 2.0 Date Released: 2023-03-10 Participants: 309
Files: 14990 Size: 159.55 GB
DOI: 10.60955/mnwq-sq07 ARK ID: 70798/d7v9bn9dj0pkm2rb7j

Cohorts: Major Depressive Disorder, Healthy Controls

Scans: EEG (resting state), fMRI (resting state), DTI, T1W, PDT2

Tasks: Emotional Face Categorization/Conflict Task (fMRI), go/no-go task (fMRI), anhedonia task (fMRI)

Timepoints: Baseline, Phase 1 (Week 2, Week 4, Week 6, Week 8), (Phase 2 coming soon)

Modalities: fMRI, Structural MRI, Diffusion tensor imaging, Electroencephalography, Genomics, Metabolomics, Methylation, Inflammatory markers

Formats: BVAL, BVEC, CSV, EDAT, EDF, FDT, JSON, NIfTI, SET

For further information


EpUp Study: A Pilot Intervention for People with Epilepsy & Depression

Hum, K. M., Chan, C. J., Gane, J., Conway, L., McAndrews, M. P., & Smith, M. L.
About one third of people with epilepsy experience comorbid depression. UPLIFT (Using Practice and Learning to Increase Favorable Thoughts) uses mindfulness-based cognitive behavioural therapy (CBT) principles to treat depression in people with epilepsy. The EpUp study aimed to examine outcomes of UPLIFT versus EpINFO, an epilepsy information and self-management program. The effects of these distance-delivery, group intervention programs were studied in adults with epilepsy and self-reported depressive symptoms...

Version: 1.0 Date Released: 2022-11-25
Participants: 66 Files: 240 Size: 10.13 MB
DOI: 10.60955/vp3k-4y63 ARK ID: 70798/d7k2604zp75tn8bkb1

Cohorts: UpLift, EpInfo, Wait-List Control

Timepoints: Pre Waitlist (T1), Pre Intervention (T1/T1a), Post Intervention (T2), Short Term Followup (T3), Long Term Followup (T4)

Modalities: Clinical studies, Distance-delivery, Group intervention, Mindfulness cognitive behavior therapy, Self-management

Formats: CSV

For further information

Do distance-delivery group interventions improve depression in people with epilepsy?

Hum KM, Chan CJ, Gane J, Conway L, McAndrews MP & Smith ML (2019). Epilepsy & behavior.

CP-NET: Hemi-NET Clinical Database

Cerebral Palsy Neuroscience Discovery Network (CP-NET)
This controlled data release focuses on CP-NET's initial Clinical Database which solely focused on children and youth, aged 2-18, with a confirmed diagnosis of hemiplegic cerebral palsy (CP). The Hemi-NET Clinical Database has data on 320 children and youth from across Ontario...

Version: 1.0 Date Released: 2022-10-17 Participants: 320
Files: 14 Size: 47.24 GB
DOI: 10.60955/8q2t-cv21 ARK ID: 70798/d7wx86hhx5mj34339s

Conditions: Cerebral palsy, hemiplegic

Scans: MR-T1w, MR-T2w, MR-FLAIR, DTI, Angio, CT, MR-PDT2, MR-PDw, MRS

Timepoints: Phase 1 Data - Single Time Point

Modalities: Genomics, clinical studies, patient registry, neuroimaging

Formats: CSV, BVAL, BVEC, NIfTI, PDF, CEL, CYHD.CYCHP

For further information

Neurodevelopmental profiles of children with unilateral cerebral palsy associated with middle cerebral artery and periventricular venous infarctions.

Fehlings D, Krishnan P, Ragguett RM, deVeber G, Gorter JW, Hunt C, Kim M, Mesterman R. McCormick A & CP-NET Group (2021). Dev Med Child Neurol.


Additional Resources

About CP-NET Hemi-NET CP-NET Videos


Province of Ontario Neurodevelopmental Disorders Network (POND) Imaging Data

Dr. Evdokia Anagnostou, Dr. Jason Lerch, Dr. Paul D. Arnold, Dr. Rob Nicolson, Dr. Stelios Georgiades, Dr. Stephen W. Scherer, Dr. Russell Schachar, Dr. Jennifer Crosbie, Dr. Peter Szatmari, Dr. Xudong Liu, Dr. Elizabeth Kelley, Dr. Muhammad Ayub and Dr. Karun Singh. POND Network
The Province of Ontario Neurodevelopmental Disorders (POND) Network is an Integrated Discovery Program funded by the Ontario Brain Institute and aims to understand the neurobiology of neurodevelopment disorders and translate the findings into effective new treatments...

Version: 1.0 Date Released: 2022-02-22 Participants: 682
Files: 179 Size: 303 GB
DOI: 10.60955/n327-cd87 ARK ID: 70798/d7qv7rj6b98w66v7m3

Conditions: ADHD, Autism spectrum disorder, Obsessive-compulsive disorder, Anxiety, Fragile X syndrome, 22q11.2 deletion syndrome, Tourette's syndrome

Scans: MR-T1 & MR-T2 (anatomy), DTI (resting state), MRS, MRS (GABA-ACC), MEG (resting state), GRE

Tasks: Emotion processing fMRI task paradigm (faces), Social cognition (theory of mind) fMRI task, Stop signal task (fMRI), Set-shifting task (MEG), Go/no-go task (MEG), Social attribution task (MEG), Inscape task (MEG)

Timepoints: Single Timepoint

Modalities: Genetics, Neuroimaging, MRI, MEG, Neurobiology

Formats: CSV, PDF, TXT, NIfTI, MEG, RDA

For further information

Oxytocin receptor polymorphisms are differentially associated with social abilities across neurodevelopmental disorders.

Baribeau DA, Dupuis A, Paton TA, Scherer SW, Schachar RJ, Arnold PD, Szatmari P, Nicolson R, Georgiades S, Crosbie J, Brian J, Iaboni A, Lerch J & Anagnostou E (2017). Scientific reports.

Province of Ontario Neurodevelopmental Disorders Network (POND) Registry Clinical Data

Dr. Evdokia Anagnostou, Dr. Jason Lerch, Dr. Paul D. Arnold, Dr. Rob Nicolson, Dr. Stelios Georgiades, Dr. Stephen W. Scherer, Dr. Russell Schachar, Dr. Jennifer Crosbie, Dr. Peter Szatmari, Dr. Xudong Liu, Dr. Elizabeth Kelley, Dr. Muhammad Ayub and Dr. Karun Singh. POND Network
The Province of Ontario Neurodevelopmental Disorders (POND) Network is an Integrated Discovery Program funded by the Ontario Brain Institute, and aims to understand the neurobiology of neurodevelopment disorders and translate the findings into effective new treatments. Neurodevelopmental disorders investigated as part of this program include attention deficit/hyperactivity disorder, autism spectrum disorder, intellectual disability, obsessive compulsive disorder, Tourette syndrome, Rett syndrome, Down syndrome, Fragile X syndrome and any other genetic differences associated with neurodevelopmental disorder difficulties...

Version: 1.0 Date Released: 2021-05-03 Participants: 2784
Files: 15 Size: 1.2 GB
DOI: 10.60955/j1f9-ex49 ARK ID: 70798/d7tm3tfvt75mn87bjq

Conditions: ADHD, Autism spectrum disorder, Intellectual Disability, Obsessive-compulsive disorder, Anxiety, Rett Syndrome, Down's Syndrome, Fragile X syndrome, 22q11.2 deletion syndrome, Tourette's syndrome, Social (pragmatic) communication disorder

Timepoints: Registry

Modalities: Patient registry, Clinical studies

Formats: CSV

For further information

Oxytocin receptor polymorphisms are differentially associated with social abilities across neurodevelopmental disorders. Scientific reports.

Baribeau DA, Dupuis A, Paton TA, Scherer SW, Schachar RJ, Arnold PD, Szatmari P, Nicolson R, Georgiades S, Crosbie J, Brian J, Iaboni A, Lerch J & Anagnostou E (2017). Scientific Reports.

5P: Predicting Persistent Postconcussive Problems in Pediatrics

Dr. Roger Zemek, Dr. Martin Osmond and the Pediatric Emergency Research Canada (PERC) Concussion Team
Concussion is a common injury occurring in children and adolescents, and results in a wide variety of effects spanning physical, cognitive (thinking), psychological/behavioural, or sleep. While most cases of concussion improve within weeks, approximately one third of children have on-going symptoms for longer than 1 month, known as persistent post concussive symptoms (PPCS)...

Version: 1.0 Date Released: 2021-05-03 Participants: 3063
Files: 2 Size: 141 MB
DOI: 10.60955/6bbr-f440 ARK ID: 70798/d7br8mdvk9k9x2bd4x

Conditions: Concussion

Timepoints: Enrollment, Week 1 Follow-up, Week 2 Follow-up, Week 4 Follow-up, Week 8 Follow-up, Week 12 Follow-up

Modalities: Clinical studies

Formats: CSV

For further information

Predicting and preventing postconcussive problems in paediatrics (5P) study: protocol for a prospective multicentre clinical prediction rule derivation study in children with concussion.

Zemek R, Osmond MH & Barrowman N for PERC Concussion Team. (2013) BMJ Open.

Clinical Risk Score for Persistent Postconcussion Symptoms Among Children With Acute Concussion in the ED.

Zemek R, Barrowman N, Freedman S, et al. for the Pediatric Emergency Research Canada (PERC) Concussion Team. (2016). JAMA.


Additional Resources

About 5P 5P Publications